In this work, two solid-phases based on imidazolium-based ionic liquids were obtained and characterized for solid-phase extraction of fluoroquinolones. The process of immobilization was performed replacing a toxic reagent by UV-irradiation to get a harmless process. The obtained solid-phases were characterized by nuclear magnetic resonance spectroscopy and elemental analysis. Each solid-phase was packed in a cartridge and was used in solid-phase extraction processes for norfloxacin and ciprofloxacin, after the optimization of some parameters such as the elution solvent, the eluent volume and, the sample volume to be used during the loading step. The developed solid-phases with immobilized ionic liquids were successfully implemented for the studied compounds and indicate high probabilities to be useful in solid-phase extractions of other fluoroquinolones.