Prenatal exposure to traffic and ambient air pollution and infant weight and adiposity: The Healthy Start study

Anne P Starling; Brianna F Moore; Deborah S K Thomas; Jennifer L Peel; Weiming Zhang; John L Adgate; Sheryl Magzamen; Sheena E Martenies; William B Allshouse; Dana Dabelea

doi:10.1016/j.envres.2020.109130

Prenatal exposure to traffic and ambient air pollution and infant weight and adiposity: The Healthy Start study

Environ Res. 2020 Mar:182:109130. doi: 10.1016/j.envres.2020.109130. Epub 2020 Jan 10.

Authors

Affiliations

¹ Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: anne.starling@cuanschutz.edu.
² Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³ Department of Geography and Earth Sciences, University of North Carolina Charlotte, NC, USA.
⁴ Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
⁵ Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
⁶ Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
⁷ Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA; Department of Epidemiology, Colorado School of Public Health, Colorado State University, Fort Collins, CO, USA.
⁸ Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Abstract

Background: Prenatal exposures to ambient air pollution and traffic have been associated with adverse birth outcomes, and may also lead to an increased risk of obesity. Obesity risk may be reflected in changes in body composition in infancy.

Objective: To estimate associations between prenatal ambient air pollution and traffic exposure, and infant weight and adiposity in a Colorado-based prospective cohort study.

Methods: Participants were 1125 mother-infant pairs with term births. Birth weight was recorded from medical records and body composition measures (fat mass, fat-free mass, and adiposity [percent fat mass]) were evaluated via air displacement plethysmography at birth (n = 951) and at ~5 months (n = 574). Maternal residential address was used to calculate distance to nearest roadway, traffic density, and ambient concentrations of fine particulate matter (PM_2.5) and ozone (O₃) via inverse-distance weighted interpolation of stationary monitoring data, averaged by trimester and throughout pregnancy. Adjusted linear regression models estimated associations between exposures and infant weight and body composition.

Results: Participants were urban residents and diverse in race/ethnicity and socioeconomic status. Average ambient air pollutant concentrations were generally low; the median, interquartile range (IQR), and range of third trimester concentrations were 7.3 μg/m³ (IQR: 1.3, range: 3.3-12.7) for PM_2.5 and 46.3 ppb (IQR: 18.4, range: 21.7-63.2) for 8-h maximum O_3. Overall there were few associations between traffic and air pollution exposures and infant outcomes. Third trimester O₃ was associated with greater adiposity at follow-up (2.2% per IQR, 95% CI 0.1, 4.3), and with greater rates of change in fat mass (1.8 g/day, 95% CI 0.5, 3.2) and adiposity (2.1%/100 days, 95% CI 0.4, 3.7) from birth to follow-up.

Conclusions: We found limited evidence of an association between prenatal traffic and ambient air pollution exposure and infant body composition. Suggestive associations between prenatal ozone exposure and early postnatal changes in body composition merit further investigation.

Keywords: Adiposity; Air pollution; Infant; Pregnancy; Traffic.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adiposity*
Air Pollutants* / toxicity
Air Pollution*
Birth Weight*
Female
Humans
Infant
Male
Obesity
Particulate Matter
Pregnancy
Prenatal Exposure Delayed Effects*
Prospective Studies
Vehicle Emissions* / toxicity

Substances

Air Pollutants
Particulate Matter
Vehicle Emissions

Abstract

Publication types

MeSH terms

Substances

Grants and funding