Absorption, Fluorescence, and Two-Photon Excitation Ability of 5-Phenylisolidolo[2,1- a]quinolines

Ramon Francisco Avena; Lin Qiao; Yuki Fujii; Kohei Otomo; Hirokazu Ishii; Takeyuki Suzuki; Hirofumi Tsujino; Tadayuki Uno; Yasuo Tsutsumi; Yusuke Kawashima; Tatsuya Takagi; Kenichi Murai; Tomomi Nemoto; Mitsuhiro Arisawa

doi:10.1021/acsomega.9b04070

Absorption, Fluorescence, and Two-Photon Excitation Ability of 5-Phenylisolidolo[2,1- a]quinolines

ACS Omega. 2020 Jan 27;5(5):2473-2479. doi: 10.1021/acsomega.9b04070. eCollection 2020 Feb 11.

Authors

Ramon Francisco Avena¹, Lin Qiao², Yuki Fujii¹, Kohei Otomo^{2

3

4

5}, Hirokazu Ishii^{2

4

5}, Takeyuki Suzuki⁶, Hirofumi Tsujino¹, Tadayuki Uno¹, Yasuo Tsutsumi¹, Yusuke Kawashima¹, Tatsuya Takagi¹, Kenichi Murai¹, Tomomi Nemoto^{2

3

4

5}, Mitsuhiro Arisawa¹

Affiliations

¹ Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0874, Japan.
² Research Institute for Electronic Science, Hokkaido University, Kita 20 Nishi 10, Kita-ku, Sapporo 001-0020, Japan.
³ Graduate School of Information Science and Technology, Hokkaido University, Kita 14 Nishi 9, Kita-ku, Sapporo 060-0814, Japan.
⁴ Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Higashiyama5-1, Myodaiji, Okazaki 444-8787, Japan.
⁵ National Institute for Physiological Science, National Institutes of Natural Sciences, Higashiyama5-1, Myodaiji, Okazaki 444-8787, Japan.
⁶ The Institute of Scientific and Industrial Research, Osaka University, Mihoga-oka, Ibaraki, Osaka 567-0047, Japan.

Abstract

We report on the absorption, fluorescence, and two-photon excitation spectra of a series of 5-phenylisoindolo[2,1-a]quinoline dyes. Depending on the substituents, we observed increasing two-photon absorption cross sections, with values up to 56 GM@973 nm, which are similar to those of the enhanced green fluorescent protein and fluorescein, common fluorescent chromophores.