Zeolites in drug delivery: Progress, challenges and opportunities

Drug Discov Today. 2020 Apr;25(4):642-656. doi: 10.1016/j.drudis.2020.02.005. Epub 2020 Feb 13.

Abstract

There are continuing attempts to achieve appropriate controlled-release therapeutic systems by designing innovative functional drug delivery systems (DDS). Although various types of delivery system have been developed, strategies that have successfully made it to the clinic are rare. Given their diverse structures, zeolites have attracted significant research attention for controlled and targeted drug delivery purposes. The structure of zeolites can be microporous, mesoporous or macroporous, which can be exploited to deliver a variety of therapeutic agents to the target site in a controlled manner. In this review, we introduce the different types of zeolite, and discuss the challenges and opportunities associated with their usage as drug delivery systems.

Publication types

  • Review

MeSH terms

  • Animals
  • Delayed-Action Preparations
  • Drug Carriers / chemistry*
  • Drug Delivery Systems*
  • Drug Development
  • Humans
  • Porosity
  • Zeolites / chemistry*

Substances

  • Delayed-Action Preparations
  • Drug Carriers
  • Zeolites