Biocompatibility and osseointegration of nanostructured titanium dental implants in minipigs

Clin Oral Implants Res. 2020 Jun;31(6):526-535. doi: 10.1111/clr.13589. Epub 2020 Feb 28.

Abstract

Objectives: It is well known that surface treatments of dental implants have a great impact on their rate of osseointegration. The aim of this study was to compare the biocompatibility and the bone-implant contact (BIC) of titanium dental implants with different surface treatments.

Material and methods: Test implants (Biotech Dental) had a nanostructured surface and control implants (Anthogyr) were grit-blasted with biphasic calcium phosphate and acid-etched surface. Both titanium implants were inserted in mandible and maxillary bones of 6 Yucatan minipigs for 4 and 12 weeks (n = 10 implants/group). Biocompatibility and osseointegration were evaluated by non-decalcified histology and back-scattered electron microscopy images.

Results: The reading of histology sections by an antomo-pathologist indicated that the test implants were considered non-irritating to the surrounding tissues and thus biocompatible compared with control implants. The BIC values were higher for test than for control dental implants at both 4 and 12 weeks.

Conclusions: In summary, the new nanostructured titanium dental implant is considered biocompatible and showed a better osseointegration than the control implant at both 4 and 12 weeks.

Keywords: dental implants; nanostructured surface; osseointegration.

MeSH terms

  • Animals
  • Dental Implantation, Endosseous
  • Dental Implants*
  • Dental Prosthesis Design
  • Osseointegration*
  • Surface Properties
  • Swine
  • Swine, Miniature
  • Titanium

Substances

  • Dental Implants
  • Titanium

Grants and funding