Evaluation of chlorine substituted hydroxyapatite (ClHAP)/polydopamine composite coatings on Ti64

Colloids Surf B Biointerfaces. 2020 May:189:110799. doi: 10.1016/j.colsurfb.2020.110799. Epub 2020 Jan 28.

Abstract

Titanium (Ti) and its alloys (especially Ti-6Al-4V or Ti64) are commonly used as load-bearing implants because of their biocompatibility and resistance to fatigue and corrosion. However, Ti/alloys are bio-inert metals and not prone to osseointegration. In order to further improve the bioactivity and osseointegration of Ti64, this study evaluated the modification of the Ti64 surface with a deposited chlorine substituted hydroxyapatite (ClHAP)/polydopamine (Pda) composite coating. Pda serves as an adhesion molecule and ClHAP releases slight acidity that stimulates osteoclastic activity. The composite coating with 10-30 % ClHAP particles is shown to promote bioactivity as evidenced by osteoblast proliferation. Therefore, this coating approach may enhance osseointegration in vivo.

Keywords: Chlorine; Dopamine; Hydroxyapatite; Osteoblasts; Roughness.

MeSH terms

  • 3T3 Cells
  • Animals
  • Cell Adhesion
  • Cell Proliferation
  • Cells, Cultured
  • Chlorine / chemistry*
  • Coated Materials, Biocompatible / chemistry*
  • Durapatite / chemistry*
  • Indoles / chemistry*
  • Mice
  • Particle Size
  • Polymers / chemistry*
  • Surface Properties
  • Titanium / chemistry*

Substances

  • Coated Materials, Biocompatible
  • Indoles
  • Polymers
  • polydopamine
  • Chlorine
  • Durapatite
  • Titanium