Investigating the effects of ebselen, a potential new lithium mimetic, on glutamate transmission

Synapse. 2020 Jul;74(7):e22151. doi: 10.1002/syn.22151. Epub 2020 Mar 3.

Abstract

Ebselen, a potential new lithium-like drug, treatment reduced brain glutamate, as measured by PET imaging using the mGluR5 radioligand [18 F]FPEB in rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Azoles / pharmacology*
  • Brain / diagnostic imaging
  • Brain / drug effects*
  • Glutamic Acid / metabolism*
  • Isoindoles
  • Organoselenium Compounds / pharmacology*
  • Positron-Emission Tomography
  • Protein Binding
  • Psychotropic Drugs / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Metabotropic Glutamate 5 / metabolism*
  • Synaptic Transmission*

Substances

  • Azoles
  • Isoindoles
  • Organoselenium Compounds
  • Psychotropic Drugs
  • Receptor, Metabotropic Glutamate 5
  • Glutamic Acid
  • ebselen