Calcium Transport Proteins in Fungi: The Phylogenetic Diversity of Their Relevance for Growth, Virulence, and Stress Resistance

Abstract

The key players of calcium (Ca²⁺) homeostasis and Ca²⁺ signal generation, which are Ca²⁺ channels, Ca²⁺/H⁺ antiporters, and Ca²⁺-ATPases, are present in all fungi. Their coordinated action maintains a low Ca²⁺ baseline, allows a fast increase in free Ca²⁺ concentration upon a stimulus, and terminates this Ca²⁺ elevation by an exponential decrease - hence forming a Ca²⁺ signal. In this respect, the Ca²⁺ signaling machinery is conserved in different fungi. However, does the similarity of the genetic inventory that shapes the Ca²⁺ peak imply that if "you've seen one, you've seen them all" in terms of physiological relevance? Individual studies have focused mostly on a single species, and mechanisms elucidated in few model organisms are usually extrapolated to other species. This mini-review focuses on the physiological relevance of the machinery that maintains Ca²⁺ homeostasis for growth, virulence, and stress responses. It reveals common and divergent functions of homologous proteins in different fungal species. In conclusion, for the physiological role of these Ca²⁺ transport proteins, "seen one," in many cases, does not mean: "seen them all."

Keywords: calcium channel; calcium proton antiporter; calcium pump; calcium signal; calcium signaling; filamentous fungi; yeast.