New thymol and isothymol derivatives from Eupatorium fortunei and their cytotoxic effects

Bioorg Chem. 2020 May:98:103644. doi: 10.1016/j.bioorg.2020.103644. Epub 2020 Feb 4.

Abstract

Four new thymol derivatives (1-4), one new isothymol derivative (5), together with one known analogue (6) were isolated from the overground parts of Eupatorium fortunei. The structures were elucidated by extensive spectroscopic data analysis, including UV, IR, HR-ESIMS, 1D-, and 2D-NMR data. All compounds were evaluated for their cytotoxic effects against four human cancer cell lines using MTT assay. Compounds 1, 2, and 6 showed cytotoxicities with IC50 values 6.24-11.96 μM against MCF-7, HeLa, A549, and Hep G-2 cell lines.

Keywords: Cytotoxic effects; Eupatorium fortunei; Isothymol derivative; Thymol derivatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Eupatorium / chemistry*
  • Humans
  • Molecular Structure
  • Structure-Activity Relationship
  • Thymol / analogs & derivatives
  • Thymol / chemistry
  • Thymol / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Thymol