Butler enables rapid cloud-based analysis of thousands of human genomes

Nat Biotechnol. 2020 Mar;38(3):288-292. doi: 10.1038/s41587-019-0360-3. Epub 2020 Feb 5.

Abstract

We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cloud Computing
  • Computational Biology / methods*
  • Genome, Human*
  • Humans
  • Neoplasms / genetics*
  • Software