Efficient photosensitizers with aggregation-induced emission characteristics for lysosome- and Gram-positive bacteria-targeted photodynamic therapy

Jiabao Zhuang; Hanxiao Yang; Yue Li; Bing Wang; Nan Li; Na Zhao

doi:10.1039/d0cc00394h

Efficient photosensitizers with aggregation-induced emission characteristics for lysosome- and Gram-positive bacteria-targeted photodynamic therapy

Chem Commun (Camb). 2020 Feb 27;56(17):2630-2633. doi: 10.1039/d0cc00394h.

Authors

Jiabao Zhuang¹, Hanxiao Yang¹, Yue Li¹, Bing Wang¹, Nan Li¹, Na Zhao¹

Affiliation

¹ Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, School of Chemistry & Chemical Engineering, Shaanxi Normal University, 710119 Xi'an, China. nli@snnu.edu.cn nzhao@snnu.edu.cn.

PMID: 32016259
DOI: 10.1039/d0cc00394h

Abstract

Two efficient photosensitizers (PSs) with aggregation-induced emission characteristics were designed and synthesized for specific lysosome-targeted photodynamic therapy (PDT). Both PSs efficiently discriminated Gram-positive bacteria from Gram-negative bacteria and killed Gram-positive bacteria through the PDT effect.

MeSH terms

Gram-Positive Bacteria / drug effects*
Gram-Positive Bacteria / metabolism
HeLa Cells
Humans
Lysosomes / drug effects*
Lysosomes / metabolism
Photochemotherapy*
Photosensitizing Agents / pharmacology*
Reactive Oxygen Species / metabolism
Superoxides / metabolism

Substances

Photosensitizing Agents
Reactive Oxygen Species
Superoxides