Pharmacogenomics: An evolving clinical tool for precision medicine

Jennifer K Hockings; Amy L Pasternak; Angelika L Erwin; Neil T Mason; Charis Eng; J Kevin Hicks

doi:10.3949/ccjm.87a.19073

Pharmacogenomics: An evolving clinical tool for precision medicine

Cleve Clin J Med. 2020 Feb;87(2):91-99. doi: 10.3949/ccjm.87a.19073.

Authors

Jennifer K Hockings¹, Amy L Pasternak², Angelika L Erwin³, Neil T Mason⁴, Charis Eng⁵, J Kevin Hicks⁶

Affiliations

¹ Department of Pharmacy, Cleveland Clinic; Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care hockinc@ccf.org.
² Clinical Assistant Professor, Department of Clinical Pharmacy, College of Pharmacy, University of Michigan; Department of Pharmacy, Michigan Medicine, Ann Arbor, MI.
³ Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
⁴ Department of Individualized Cancer Management, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
⁵ Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care; Professor, Department of Genetics and Genomic Sciences, Case Western Reserve University School of Medicine, Cleveland, OH.
⁶ Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care; Department of Individualized Cancer Management, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

PMID: 32015062
DOI: 10.3949/ccjm.87a.19073

Abstract

Pharmacogenomics, ie, the study of how an individual's genomic profile influences his or her response to drugs, has emerged as a clinical tool to optimize drug therapy. Certain variants in some genes increase the risk of severe, life-threatening adverse effects from certain drugs. Integrating pharmacogenomics into clinical practice to assist in drug selection and dosing has the potential to improve the outcomes of treatment, reduce the risk of drug-induced morbidity and death, and be cost-effective.

Publication types

Review

MeSH terms

Antidepressive Agents, Tricyclic / adverse effects
Antidepressive Agents, Tricyclic / metabolism
Clopidogrel / metabolism
Codeine / adverse effects
Codeine / metabolism*
Cytochrome P-450 CYP2C19 / genetics
Cytochrome P-450 CYP2D6 / genetics*
Direct-To-Consumer Screening and Testing
Genetic Testing / economics
Genotype
Humans
Pharmacogenetics* / economics
Pharmacogenetics* / education
Pharmacogenetics* / organization & administration
Pharmacogenomic Variants*
Precision Medicine*
Selective Serotonin Reuptake Inhibitors / adverse effects
Selective Serotonin Reuptake Inhibitors / metabolism

Substances

Antidepressive Agents, Tricyclic
Serotonin Uptake Inhibitors
Clopidogrel
CYP2C19 protein, human
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2D6
Codeine