Constitutive description of skin dermis: Through analytical continuum and coarse-grained approaches for multi-scale understanding

Abstract

Although there are many successful descriptions of the mechanical response of dermis at different levels of complexity and incorporating varying degrees of the physical phenomena involved in deformation, observations indicate that the unraveling of fibers involves a complex three-dimensional process in which they interact in ways that resemble a braided pattern. Here we develop two complementary treatments to gain a better understanding of the mechanical response of dermis: a) an analytical treatment incorporating fibril stiffness, interfibrillar frictional sliding, and the effect of lateral fibers on the extension of a primary fiber; b) a coarse-grained molecular dynamics model comprised of an array of parallel curved fibrils simulating a fiber. Interfibrillar frictional sliding and stiffness are also captured. Both analytical and molecular dynamics models operate at a scale compatible with the wavelength of collagen fibers (~10 µm). The constitutive description presented here incorporates important physical processes taking place during deformation of dermis and thus represents an advance in our understanding of these phenomena. STATEMENT OF SIGNIFICANCE: Microstructural observations of the dermis of skin during tensile deformation indicate that the unraveling of fibers involves a complex three-dimensional process which replicates the effects of braiding. Two complementary constitutive modeling treatments were developed to gain a better understanding of the mechanical response of dermis: an analytical treatment incorporating fibril stiffness, interfibrillar sliding, and the effect of transverse fibers; and a coarse-grained molecular dynamics model describing the fibril bundling effect. An important novel aspect of the current contribution is the recognition that tridimensional collagen fiber arrangements play an important role in the mechanical response. The constitutive description presented here incorporates physical processes taking place during deformation of the dermis and thus represents an advance in our understanding of these phenomena.

Keywords: Coarse grain modeling; Collagen; Constitutive modeling; Molecular dynamics; Skin.