Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming

Jun Fang; Yuan-Yu Hsueh; Jennifer Soto; Wujin Sun; Jinqiang Wang; Zhen Gu; Ali Khademhosseini; Song Li

doi:10.1021/acsnano.9b04837

Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming

ACS Nano. 2020 Feb 25;14(2):1296-1318. doi: 10.1021/acsnano.9b04837. Epub 2020 Feb 3.

Authors

Jun Fang^{1

2}, Yuan-Yu Hsueh^{1

3}, Jennifer Soto^{1

2}, Wujin Sun^{1

4}, Jinqiang Wang^{1

4}, Zhen Gu^{1

4

5}, Ali Khademhosseini^{1

4

6

7}, Song Li^{1

2

4}

Affiliations

¹ Department of Bioengineering , University of California, Los Angeles , Los Angeles , California 90095 , United States.
² Department of Medicine , University of California, Los Angeles , Los Angeles , California 90095 , United States.
³ Division of Plastic Surgery, Department of Surgery, College of Medicine , National Cheng Kung University Hospital , Tainan 70456 , Taiwan.
⁴ Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute , University of California, Los Angeles , Los Angles , California 90095 , United States.
⁵ Jonsson Comprehensive Cancer Center , University of California, Los Angeles , Los Angeles , California 90095 , United States.
⁶ Department of Chemical and Biomolecular Engineering , University of California, Los Angeles , Los Angeles , California 90095 , United States.
⁷ Department of Radiology , University of California, Los Angeles , Los Angeles , California 90095 , United States.

Abstract

Cell reprogramming is a revolutionized biotechnology that offers a powerful tool to engineer cell fate and function for regenerative medicine, disease modeling, drug discovery, and beyond. Leveraging advances in biomaterials and micro/nanotechnologies can enhance the reprogramming performance in vitro and in vivo through the development of delivery strategies and the control of biophysical and biochemical cues. In this review, we present an overview of the state-of-the-art technologies for cell reprogramming and highlight the recent breakthroughs in engineering biomaterials with micro/nanotechnologies to improve reprogramming efficiency and quality. Finally, we discuss future directions and challenges for reprogramming technologies and clinical translation.

Keywords: biochemical cues; biomaterials; biophysical cues; cell reprogramming; drug delivery; nanotechnology; three-dimensional niches; tissue engineering.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biocompatible Materials / chemistry*
Cellular Reprogramming
Humans
Nanotechnology*
Particle Size
Surface Properties
Tissue Engineering*

Substances

Biocompatible Materials

Abstract

Publication types

MeSH terms

Substances

Grants and funding