Primary Nasal Epithelial Cells From Allergic and Non-allergic Individuals Show Comparable Barrier Function

Eva E Waltl; Victoria Stanek; Christian A Mueller; Renata Kiss; Julia Eckl-Dorna; Rudolf Valenta; Verena Niederberger

doi:10.4168/aair.2020.12.2.364

Primary Nasal Epithelial Cells From Allergic and Non-allergic Individuals Show Comparable Barrier Function

Allergy Asthma Immunol Res. 2020 Mar;12(2):364-370. doi: 10.4168/aair.2020.12.2.364.

Authors

Eva E Waltl¹, Victoria Stanek¹, Christian A Mueller¹, Renata Kiss², Julia Eckl-Dorna¹, Rudolf Valenta^{2

3

4}, Verena Niederberger⁵

Affiliations

¹ Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
² Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
³ NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
⁴ Laboratory for Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia.
⁵ Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria. verena.niederberger@meduniwien.ac.at.

Abstract

Previous reports suggested that ex vivo cultured primary nasal epithelial cells from allergic patients differ from those from non-allergic individuals by genuinely reduced barrier function. By contrast, we found that primary nasal epithelial cells from allergic and non-allergic individuals showed comparable barrier function and secretion of cytokines.

Keywords: Respiratory epithelial barrier function; allergen; allergen-microarray; allergic rhinitis; immunoglobulin E; transepithelial resistance.

Abstract

Grants and funding