Trametinib and Dabrafenib in histiocytic sarcoma transdifferentiated from chronic lymphocytic leukemia with a K-RAS and a unique BRAF mutation

MeSH terms

• Aged
• Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
• Cell Transdifferentiation*
• Head and Neck Neoplasms* / diagnostic imaging
• Head and Neck Neoplasms* / drug therapy
• Head and Neck Neoplasms* / genetics
• Head and Neck Neoplasms* / pathology
• Histiocytic Sarcoma* / diagnostic imaging
• Histiocytic Sarcoma* / drug therapy
• Histiocytic Sarcoma* / genetics
• Histiocytic Sarcoma* / pathology
• Humans
• Imidazoles / administration & dosage
• Leukemia, Lymphocytic, Chronic, B-Cell* / diagnostic imaging
• Leukemia, Lymphocytic, Chronic, B-Cell* / drug therapy
• Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
• Leukemia, Lymphocytic, Chronic, B-Cell* / pathology
• Male
• Oximes / administration & dosage
• Proto-Oncogene Proteins B-raf / genetics*
• Proto-Oncogene Proteins p21(ras) / genetics*
• Pyridones / administration & dosage
• Pyrimidinones / administration & dosage