Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma

Affiliations

• ¹ Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
• ² Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
• ³ Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, 200032, China.
• ⁴ Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
• ⁵ Cancer Institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China.
• ⁶ Institute of Radiation Medicine, Fudan University, Shanghai, 200032, China.
• ⁷ MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
• ⁸ Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
• ⁹ Institute of Radiation Medicine and Fudan University Shanghai Cancer Center, Shanghai Medical school, Fudan University, Shanghai, 200032, China. guoqianghua@fudan.edu.cn.
• ¹⁰ Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. pengjj67@hotmail.com.
• ¹¹ Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. pengjj67@hotmail.com.
• ¹² Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, 200032, China. fxyu@fudan.edu.cn.
• ¹³ Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. fxyu@fudan.edu.cn.