Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis

Immunobiology. 2020 May;225(3):151905. doi: 10.1016/j.imbio.2020.151905. Epub 2020 Jan 22.

Abstract

We conducted a prospective study of 453 Polish patients suffering from pulmonary tuberculosis and 267 healthy controls. Selected polymorphisms of the genes encoding for collectins, ficolins and MBL-associated serine protease 2 were investigated as were serum concentrations of mannose-binding lectin, surfactant protein D, ficolin-1 and ficolin-3. The number of MBL2 gene exon 1 variant allele carriers was significantly higher in patients, compared with controls. The homozygosity for SFTPA2 +26 C > A SNP variant allele occurred less commonly within TB, while homozygosity for the FCN1 -542 G > A major allele was less frequent within the control group. Two patients were found MASP-2-deficient. Serum concentrations of MBL, SP-D and ficolin-1 were higher amongst patients while the converse was found for ficolin-3. Ficolin-1 had high specificity to differentiate between individuals with tuberculosis and healthy persons and therefore may be considered potential disease marker.

Keywords: Collectin; Ficolin; MASP; Pulmonary surfactant; Tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Disease Susceptibility*
  • Ficolins
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Immunity, Innate*
  • Lectins / genetics
  • Mannose-Binding Lectin
  • Poland
  • Polymorphism, Single Nucleotide
  • Prospective Studies
  • Risk Assessment
  • Risk Factors
  • Tuberculosis, Pulmonary / epidemiology*
  • Tuberculosis, Pulmonary / etiology*

Substances

  • Lectins
  • MBL2 protein, human
  • Mannose-Binding Lectin