Natural products target the hallmarks of chronic diseases

Abstract

Natural compounds are known to display therapeutic potential against a variety of chronic conditions, including cancer and inflammation. The efficacy of these natural substances can be associated with numerous molecular scaffolds present in extracts of living organisms, both terrestrial and marine. Recently, investigators have identified the ability of natural compounds to trigger immunogenic cell death and subsequent activation of the adaptive immune system. Such findings indicate that the full therapeutic potential of natural products has yet to be defined, and further investigations on such agents will continue to yield novel drug candidates.

Keywords: Antiaging; Natural compounds; Noncommunicable disease; Nuclear factor erythroid 2-related factor 2; Polyphenol; Polyunsaturated fatty acid.