Electrochemical cytosensors for detection of breast cancer cells

Fereshteh Vajhadin; Samad Ahadian; Jadranka Travas-Sejdic; Junmin Lee; Mohammad Mazloum-Ardakani; Jocelynda Salvador; George E Aninwene 2nd; Praveen Bandaru; Wujin Sun; Ali Khademhossieni

doi:10.1016/j.bios.2019.111984

Electrochemical cytosensors for detection of breast cancer cells

Biosens Bioelectron. 2020 Mar 1:151:111984. doi: 10.1016/j.bios.2019.111984. Epub 2019 Dec 24.

Affiliations

¹ Department of Chemistry, University of Yazd, Yazd, Yazd, 89195-741, Iran; Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA; Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095, USA.
² Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA; Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095, USA.
³ Polymer Electronics Research Centre, School of Chemical Sciences, The University of Auckland, Auckland, 1010, New Zealand; MacDiarmid Institute for Advanced Materials and Nanotechnology, Wellington, 6140, New Zealand.
⁴ Department of Chemistry, University of Yazd, Yazd, Yazd, 89195-741, Iran. Electronic address: mazloum@yazd.ac.ir.
⁵ Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA; Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095, USA; Department of Radiological Sciences, University of California-Los Angeles, Los Angeles, CA, 90095, USA; Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: khademh@ucla.edu.

PMID: 31999590
DOI: 10.1016/j.bios.2019.111984

Abstract

Breast cancer is one of lethal cancers among women with its metastasis leading to cancer-related morbidity and mortality. Circulating tumor cells (CTCs) derived from a primary tumor can be detected in the venous blood of cancer patients. Monitoring CTCs in blood samples has increased exponentially over the past decades and holds great promise in the diagnosis and treatment of metastatic breast cancer. Electrochemical cytosensors, classified as a class of electrochemical biosensors for sensitive detection and enumeration of targeted cells with minimally invasive methods, have the advantages of electrochemical biosensors, such as simplicity, low cost, and low limit of detection. Here, we review recent progress in the detection of CTCs from breast cancer with a focus on electrochemical cytosensors. This review describes platforms benefiting from these cytosensors to identify cancerous breast cells. Furthermore, strategies for signal amplification and also generation of reusable electrochemical cytosensors are introduced. In addition, breast cancer markers and biorecognition elements for cell capturing are reviewed.

Keywords: Biosensors; Breast cancer cells; Circulating tumor cells; Electrochemical cytosensors; Reusable cytosensors; Tumor markers.

Publication types

Review

MeSH terms

Biomarkers, Tumor / genetics
Biomarkers, Tumor / isolation & purification*
Biosensing Techniques*
Breast Neoplasms / blood*
Breast Neoplasms / genetics
Breast Neoplasms / pathology
Cell Separation / methods
Female
Humans
Neoplastic Cells, Circulating / pathology*

Substances

Biomarkers, Tumor