Core-Shell-Heterostructured Magnetic-Plasmonic Nanoassemblies with Highly Retained Magnetic-Plasmonic Activities for Ultrasensitive Bioanalysis in Complex Matrix

Liangwen Hao; Yuankui Leng; Lifeng Zeng; Xirui Chen; Jing Chen; Hong Duan; Xiaolin Huang; Yonghua Xiong; Xiaoyuan Chen

doi:10.1002/advs.201902433

Core-Shell-Heterostructured Magnetic-Plasmonic Nanoassemblies with Highly Retained Magnetic-Plasmonic Activities for Ultrasensitive Bioanalysis in Complex Matrix

Adv Sci (Weinh). 2019 Dec 13;7(2):1902433. doi: 10.1002/advs.201902433. eCollection 2020 Jan.

Authors

Liangwen Hao¹, Yuankui Leng¹, Lifeng Zeng², Xirui Chen¹, Jing Chen¹, Hong Duan¹, Xiaolin Huang¹, Yonghua Xiong¹, Xiaoyuan Chen³

Affiliations

¹ State Key Laboratory of Food Science and Technology School of Food Science and Technology Jiangxi Key Laboratory for Microscale Interdisciplinary Study Nanchang University Nanchang 330047 P. R. China.
² The People's Hospital in Jiangxi Province Nanchang 330006 P. R. China.
³ Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH) Bethesda MD 20892 USA.

Abstract

Herein, a facile self-assembly strategy for coassembling oleic acid-coated iron oxide nanoparticles (OC-IONPs) with oleylamine-coated gold nanoparticles (OA-AuNPs) to form colloidal magnetic-plasmonic nanoassemblies (MPNAs) is reported. The resultant MPNAs exhibit a typical core-shell heterostructure comprising aggregated OA-AuNPs as a plasmonic core surrounded by an assembled magnetic shell of OC-IONPs. Owing to the high loading of OA-AuNPs and reasonable spatial distribution of OC-IONPs, the resultant MPNAs exhibit highly retained magnetic-plasmonic activities simultaneously. Using the intrinsic dual functionality of MPNAs as a magnetic separator and a plasmonic signal transducer, it is demonstrated that the assembled MPNAs can achieve the simultaneous magnetic manipulation and optical detection on the lateral flow immunoassay platform after surface functionalization with recognition molecules. In conclusion, the core-shell-heterostructured MPNAs can serve as a nanoanalytical platform for the separation and concentration of target compounds from complex biological samples using magnetic properties and simultaneous optical sensing using plasmonic properties.

Keywords: core–shell heterostructures; highly retained magnetic‐plasmonic activities; lateral flow immunoassays; magnetic–plasmonic nanoassemblies; self‐assembly.