The Role of Cardiovascular Imaging and Serum Biomarkers in Identifying Cardiotoxicity Related to Cancer Therapeutics

Methodist Debakey Cardiovasc J. 2019 Oct-Dec;15(4):258-266. doi: 10.14797/mdcj-15-4-258.

Abstract

Innovations and discoveries in cancer therapeutics have improved survival rates in patients with various types of malignancies. At the same time, physicians are identifying an increased number of patients with treatment-related cardiotoxicity. It is imperative that physicians recognize early treatment-related adverse effects to determine the safest therapeutic options for patients with cancer. This manuscript evaluates the role of cardiovascular imaging and biomarkers in identifying cardiotoxicity trigged by various chemotherapeutic agents and summarizes expert consensus statements regarding cardiotoxicity monitoring.

Keywords: CMR; anthracyclines; biomarkers; cardiac magnetic resonance; cardiotoxicity; echocardiogram; immune checkpoint inhibitors.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects*
  • Biomarkers / blood*
  • Cardiac Imaging Techniques*
  • Cardiotoxicity
  • Early Diagnosis
  • Heart Diseases / blood*
  • Heart Diseases / chemically induced
  • Heart Diseases / diagnostic imaging*
  • Heart Diseases / physiopathology
  • Humans
  • Predictive Value of Tests
  • Risk Assessment
  • Risk Factors

Substances

  • Antineoplastic Agents
  • Biomarkers