Hepatoprotective lignans and triterpenoids from the roots of Kadsura longipedunculata

Abstract

Two new tetrahydrobenzocyclooctabenzofuranone lignans (1-2), a new dibenzocyclooctadiene lignan (3) and three new schiartane-type triterpenoids (4-6), together with six known compounds (7-12), were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by extensive NMR and HRESIMS spectroscopic data analysis. The absolute configurations of these compounds were determined by comparison of the experimental and calculated ECD spectra. Compound 12 exhibited moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 53.04%.

Keywords: Dibenzocyclooctadiene lignan; Hepatoprotective activity; Kadsura longipedunculata; Schiartane-type triterpenoid; Tetrahydrobenzocyclooctabenzofuranone lignan.