Histology, Goblet Cells

Excerpt

Goblet cells arise from pluripotent stem cells and derive their name from their goblet, cup-like appearance. The primary function of goblet cells is to secrete mucin and create a protective mucus layer. Goblet cells are also thought to be involved with immunoregulation. Samples of goblet cells can be preserved through cryopreservation and analyzed with light microscopy. Additionally, goblet cells exhibit a complex cytoskeletal architecture and may have different glycosylation patterns. As a result, different localized goblet cells may have slightly altered functionalities. Clinically, goblet cells are associated with respiratory diseases and inflammatory bowel diseases.