Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

Chenxi Wang; Yuan Liu; Chunyan Bao; Yuan Xue; Yaowu Zhou; Dasheng Zhang; Qiuning Lin; Linyong Zhu

doi:10.1039/c9cc09449k

Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

Chem Commun (Camb). 2020 Feb 20;56(15):2264-2267. doi: 10.1039/c9cc09449k.

Authors

Chenxi Wang¹, Yuan Liu¹, Chunyan Bao¹, Yuan Xue¹, Yaowu Zhou¹, Dasheng Zhang¹, Qiuning Lin¹, Linyong Zhu¹

Affiliation

¹ Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science & Technology, Shanghai, 200237, P. R. China. baochunyan@ecust.edu.cn linyongzhu@ecust.edu.cn.

PMID: 31984385
DOI: 10.1039/c9cc09449k

Abstract

Here we report the use of 2-nitrobenzyl alcohol (NB) as a photoreactive group with amine selectivity and explore its applications for photoaffinity labeling and crosslinking of biomolecules. This work confirms that NB is an efficient photoreactive group and has great potential in drug discovery, chemical biology and protein engineering.