Detection of extraoral primary cancers by positron emission tomography/computed tomography in patients with oral squamous cell carcinoma

Toshimitsu Ohsako; Hiroaki Shimamoto; Hirofumi Tomioka; Hideaki Hirai; Takeshi Kuroshima; Yumi Mochizuki; Takuma Kugimoto; Fumihiko Tsushima; Shin Nakamura; Tohru Kurabayashi; Hiroyuki Harada

doi:10.1016/j.oooo.2019.09.001

Detection of extraoral primary cancers by positron emission tomography/computed tomography in patients with oral squamous cell carcinoma

Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Mar;129(3):272-276. doi: 10.1016/j.oooo.2019.09.001. Epub 2019 Sep 16.

Affiliations

¹ Specially Appointed Assistant Professor, Division of Oral and Maxillofacial Surgery, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: jyukainokumasan@yahoo.co.jp.
² Assistant Professor, Division of Oral and Maxillofacial Surgery, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
³ Specially Appointed Assistant Professor, Division of Oral and Maxillofacial Surgery, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
⁴ Junior Associate Professor, Division of Oral and Maxillofacial Surgery, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
⁵ Assistant Professor, Division of Oral and Maxillofacial Radiology, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
⁶ Professor, Division of Oral and Maxillofacial Radiology, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
⁷ Professor, Division of Oral and Maxillofacial Surgery, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

PMID: 31982370
DOI: 10.1016/j.oooo.2019.09.001

Abstract

Objective: Extraoral primary cancers (EPCs) can appear in patients with oral cancer. This study investigated the use of positron emission tomography/computed tomography (PET/CT) to detect EPCs and to identify characteristics of these cancers. The disease-specific survival rate and the overall survival rate were calculated.

Study design: We studied records for 891 patients with oral cancer who underwent PET/CT between January 2006 and December 2016 for the detection of EPCs.

Results: A total of 35 EPCs were detected by PET/CT in 34 patients with primary oral carcinoma (3.8%). Of this total, 33 patients had 1 EPC and 1 patient had 2 EPCs. The extraoral lesions were found in the upper gastrointestinal tract (11), colon (6), lung (5), kidney (3), liver (2), prostate (2), breast (2), bladder (1), thyroid (1), pancreas (1), and hypopharynx (1). The disease-specific survival rate was 84.8% and the overall survival rate was 64.6%.

Conclusions: PET/CT was useful for early detection of EPCs. The use of PET/CT for the early detection and treatment of EPCs with no symptoms can improve treatment outcomes.

MeSH terms

Carcinoma, Squamous Cell*
Fluorodeoxyglucose F18
Humans
Male
Mouth Neoplasms*
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Radiopharmaceuticals
Retrospective Studies
Survival Rate

Substances

Radiopharmaceuticals
Fluorodeoxyglucose F18