Association of HLA-A*11:01 with Sulfonamide-Related Severe Cutaneous Adverse Reactions in Japanese Patients

J Invest Dermatol. 2020 Aug;140(8):1659-1662.e6. doi: 10.1016/j.jid.2019.12.025. Epub 2020 Jan 23.
No abstract available

Publication types

  • Letter
  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Drug Hypersensitivity Syndrome / genetics*
  • Female
  • Genetic Predisposition to Disease
  • HLA-A11 Antigen / genetics*
  • HLA-A11 Antigen / metabolism
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Molecular Docking Simulation
  • Skin / drug effects
  • Stevens-Johnson Syndrome / genetics*
  • Sulfamethoxazole / adverse effects
  • Sulfamethoxazole / metabolism
  • Sulfanilamide / adverse effects
  • Sulfanilamide / metabolism
  • Sulfasalazine / adverse effects
  • Sulfasalazine / metabolism
  • Sulfonamides / adverse effects*
  • Sulfonamides / metabolism

Substances

  • HLA-A*11:01 antigen
  • HLA-A11 Antigen
  • Sulfonamides
  • Sulfanilamide
  • Sulfasalazine
  • Sulfamethoxazole