Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology

Affiliations

• ¹ Reference Centre for Neuromuscular Diseases, Necker-Enfants Malades Hospital.
• ² Department of Paediatric Neurophysiology, Necker-Enfants Malades Hospital, Paris University, APHP Centre, Paris.
• ³ INSERM U955-Team 10, Department of Neurosciences, Mondor Biomedical Research Institute, Paris-Est University, Créteil.
• ⁴ Immunobiology of Dendritic Cells, Institut Pasteur, Paris.
• ⁵ INSERM U1223.
• ⁶ Chimie & Biologie, Modélisation et Immunologie pour la Thérapie (CBMIT), Université Paris Descartes, CNRS, UMR8601.
• ⁷ Laboratoire de Génétique et Biologie Moléculaires, Hôpital Cochin.
• ⁸ Laboratory of Neurogenetics and Neuroinflammation, Imagine Institute.
• ⁹ General Paediatrics, Infectious Disease and Internal Medicine Department, Hôpital Robert Debré, AP-HP.
• ¹⁰ Paediatric Hematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, AP-HP.
• ¹¹ Rheumatological and Auto-Immune diseaseS in children (RAISE) rare diseases centre.
• ¹² National and European Reference Centre for Rare Diseases of the Skin (MAGEC and ERN-Skin).
• ¹³ Department of Dermatology, Necker-Enfants Malades Hospital, APHP5.
• ¹⁴ Imagine Institute, Inserm U 1163, Paris University.
• ¹⁵ Reference Center for Neuromuscular Diseases, Necker-Enfants Malades Hospital, AP-HP.5.
• ¹⁶ Department of Pediatric Neurology, Necker-Enfants Malades Hospital, AP-HP.5, Paris University, Paris, France.
• ¹⁷ Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.