mSphere of Influence: the Mycobiota in Human Health and Disease

mSphere. 2020 Jan 22;5(1):e00974-19. doi: 10.1128/mSphere.00974-19.

Abstract

Soo Chan Lee works in the field of medical mycology. In this mSphere of Influence article, he reflects on how "Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis" (Science 336:1314-1317, 2012, https://doi.org/10.1126/science.1221789) by I. D. Iliev, V. A. Funari, K. D. Taylor, Q. Nguyen, et al., "CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi" (Science 359:232-236, 2018, https://doi.org/10.1126/science.aao1503) by I. Leonardi, X. Li, A. Semon, D. Li, et al., and "The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL" (Nature 574:264-267, 2019, https://doi.org/10.1038/s41586-019-1608-2) by B. Aykut, S. Pushalkar, R. Chen, Q. Li, et al. made an impact on him to study medically important fungi by providing a forum to understand the roles of fungal microbiota or mycobiota in human diseases and health.

Keywords: microbiota; mycobiome; mycobiota; mycology; pathogenic fungi.

MeSH terms

  • Communicable Diseases / microbiology*
  • Dysbiosis*
  • Fungi / pathogenicity*
  • Humans
  • Intestines / microbiology
  • Mycobiome*
  • Symbiosis