Decision by injection without infection

Miwa Sasai; Masahiro Yamamoto

doi:10.1084/jem.20192145

Decision by injection without infection

J Exp Med. 2020 Mar 2;217(3):e20192145. doi: 10.1084/jem.20192145.

Authors

Miwa Sasai^{1

2}, Masahiro Yamamoto^{1

2}

Affiliations

¹ Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
² Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.

Abstract

The protozoan pathogen Toxoplasma gondii co-opts host immunity by secreting various effector proteins into host cells. In this issue of JEM, Chen et al. (https://doi.org/10.1084/jem.20181757) report that T. gondii injects an effector called ROP16 without invasion to polarize macrophages toward M2 cells.

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MeSH terms

Humans
Infections*
Protozoan Proteins*
T-Lymphocytes
Toxoplasma*
Virulence

Substances

Protozoan Proteins