Abstract
Isocadiolides A-H (1-8) and cadiolide N (9), new polybrominated aromatic compounds, were isolated from a Korean Synoicum sp. ascidian. On the basis of the results of extensive spectroscopic analyses, these compounds possessed tris-bromohydroxyphenyl moieties as a common structural motif, while their cores varied [cyclopentenedione (1-5), dihydrofuran (6 and 7), pyranone (8), and furanone (9)], reflecting different extents of rearrangement and oxidation. Several of these compounds exhibited weak antibacterial activities and moderate abilities to inhibit the microbial enzymes sortase A and isocitrate lyase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoacyltransferases / chemistry*
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Animals
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / chemistry*
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Cysteine Endopeptidases / chemistry*
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Isocitrate Lyase / chemistry*
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Isocitrate Lyase / metabolism
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Molecular Structure
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Polybrominated Biphenyls / chemistry*
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Polybrominated Biphenyls / isolation & purification
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Polybrominated Biphenyls / pharmacology*
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Urochordata / chemistry*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Polybrominated Biphenyls
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Aminoacyltransferases
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sortase A
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Cysteine Endopeptidases
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Isocitrate Lyase