Associations of LIM kinase1 (LIMK1) gene single nucleotide polymorphisms with prostate cancer susceptibility in Chinese population

Wuran Wei; Guojun Zeng; Chang Liu; Bingwen Zou; Li Li

Associations of LIM kinase1 (LIMK1) gene single nucleotide polymorphisms with prostate cancer susceptibility in Chinese population

Int J Clin Exp Pathol. 2017 Sep 1;10(9):9725-9734. eCollection 2017.

Authors

Wuran Wei¹, Guojun Zeng², Chang Liu³, Bingwen Zou⁴, Li Li^{5

6}

Affiliations

¹ Institute of Urology, Department of Urology, West China Hospital, Sichuan University Chengdu, China.
² Department of Vascular Surgery, West China Hospital, Sichuan University Chengdu, China.
³ Department of Liver Surgery, West China Hospital, Sichuan University Chengdu, China.
⁴ Department of Oncology, West China Hospital, Sichuan University Chengdu, China.
⁵ Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, China.
⁶ Department of Pediatrics, West China Second University Hospital, Sichuan University Chengdu, China.

PMID: 31966855
PMCID: PMC6965917

Abstract

Background: Prostate cancer is one of the most common cancers in men. LIM kinase1 (LIMK1) is a mediator in the process of cytoskeleton reorganization and cell motility. LIMK1 is related to progression, invasiveness and metastases of prostate cancer. However, the relationship between LIMK1 single nucleotide polymorphism (SNP) and the risk of prostate cancer has not been studied.

Aim: The aim of our study is to determine the association between LIMK1 polymorphisms and the risk of prostate in a Chinese population.

Methods: This case-control study consisted of 162 prostate cancer patients and 187 healthy control subjects. Five SNPs of LIMK1 including rs2269082, rs2269081, rs178409, rs6460071 and rs710968 were genotyped using iPLEX genotyping assays on a MassARRAY^® platform.

Results: No significant relationships were found between polymorphisms genotypes and the risk of prostate cancer. Also, no significant associations were found between genotypes and the individual factors such as Gleason Score, alcohol and cigarette consuming statuses.

Conclusion: These polymorphisms of LIMK1 were not significantly associated with prostate cancer susceptibility in Chinese men.

Keywords: LIM kinase1 (LIMK1); Prostate cancer; cancer risk; gene variant; single nucleotide polymorphism.