We report an unusual case of drug-associated granulomatous CD30+ T-cell pseudolymphoma secondary to amlodipine. A 55-year-old Chinese man presented with a 6-month eruption of disseminated erythematous dermal papulonodules and annular infiltrated plaques over his neck and limbs symmetrically. Histopathology revealed a perivascular and interstitial infiltrate of histiocytes, eosinophils and morphologically normal lymphocytes associated with CD30 expression. The eruption improved rapidly after discontinuation of amlodipine and did not recur.
Keywords: CD30+ lymphoproliferative disorder; amlodipine; cutaneous T cell lymphoma; drug-associated reversible granulomatous T-cell dyscrasia; drug-induced pseudolymphoma; eosinophilia; interstitial granulomatous drug reaction; mycosis fungoides.
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