Breath analysis is a promising method for rapid, inexpensive, noninvasive disease diagnosis and health monitoring owing to the correlative relationship between breath biomarker concentrations and abnormal health conditions. However, current methods to identify and quantify breath components rely on large, bench-top analytical instruments. Carbon nanotube (CNT)-based gas sensors are desirable candidates to replace benchtop instruments because of their sensitive chemical-to-electrical transducer capability, high degree of chemical functionality options, and potential for miniaturization. This review seeks to give an overview of the synthetic methods used to functionalize CNT-based gas sensors, specifically those sensors that target biologically relevant breath markers. Specific examples are provided to highlight the sensing mechanisms behind different classes of CNT hybrid composites. Finally, the current challenges and prospective solutions of applying CNT-based sensors to breath analysis are discussed.
Keywords: breath analysis; chemiresistors; nanoparticles; nanotubes; sensors.
© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.