Coexistence of Pure Red Cell Aplasia and Autoimmune Haemolytic Anaemia Associated with Thymoma

Acta Haematol. 2020;143(5):491-495. doi: 10.1159/000503376. Epub 2020 Jan 21.

Abstract

Thymoma is an uncommon neoplasia derived from the epithelial cells of the thymus, which leads to immune dysregulation and is associated with a series of autoimmune diseases. However, the concurrence of these disease entities is rare, and the exact mechanisms of these diseases are still unclear. We have admitted several cases who were diagnosed with thymoma, autoimmune haemolytic anaemia, and pure red cell aplasia. These cases were the first to report the concurrence of these three disorders. After thymectomy, anaemia improved, haemolytic cells decreased, and haemoglobin was normalized.

Keywords: Autoimmune haemolytic anaemia; Pure red cell aplasia; Thymoma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Aged
  • Anemia, Hemolytic, Autoimmune / diagnosis*
  • Anemia, Hemolytic, Autoimmune / drug therapy
  • Anemia, Hemolytic, Autoimmune / etiology
  • Bone Marrow / pathology
  • Erythrocyte Transfusion
  • Female
  • Hemoglobins / analysis
  • Humans
  • Male
  • Middle Aged
  • Red-Cell Aplasia, Pure / diagnosis*
  • Red-Cell Aplasia, Pure / therapy
  • Thorax / diagnostic imaging
  • Thymus Neoplasms / complications
  • Thymus Neoplasms / diagnosis*
  • Tomography, X-Ray Computed

Substances

  • Adrenal Cortex Hormones
  • Hemoglobins