Successful treatment of chromoblastomycosis caused by Fonsecaea pedrosoi using imiquimod

J Dermatol. 2020 Apr;47(4):409-412. doi: 10.1111/1346-8138.15225. Epub 2020 Jan 21.

Abstract

Chromoblastomycosis (CBM) is a fungal infection caused by fungi belonging to the order Chaetothyriales, and caused mainly by Fonsecaea pedrosoi. The classic treatment, based on itraconazole and/or terbinafine as well as physical approaches, is considered complex and ineffective due to the high rate of relapses. Thus, new strategies are needed to manage CBM; in this regard, the present work reports the evolution of lesions in patients successfully treated with imiquimod. Of note, classic treatment was not effective in healing the lesions of two of them, but single topical treatment with imiquimod healed the lesions.

Keywords: Fonsecaea pedrosoi; chromoblastomycosis; imiquimod; lesion evolution; treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brazil
  • Chromoblastomycosis / diagnosis
  • Chromoblastomycosis / drug therapy*
  • Chromoblastomycosis / microbiology
  • Chromoblastomycosis / pathology
  • Fonsecaea / isolation & purification*
  • Hand
  • Humans
  • Imiquimod / administration & dosage*
  • Male
  • Middle Aged
  • Skin / microbiology
  • Skin / pathology
  • Skin Cream / administration & dosage*
  • Treatment Outcome

Substances

  • Imiquimod