Proactive Rehabilitation for Chemotherapy-Induced Peripheral Neuropathy

Semin Oncol Nurs. 2020 Feb;36(1):150983. doi: 10.1016/j.soncn.2019.150983. Epub 2020 Jan 18.

Abstract

Objective: To review assessment and management approaches for chemotherapy-induced peripheral neuropathy-related physical function deficits.

Data sources: Peer-reviewed articles from PubMed, Ovid MEDLINE, CINAHL PsycINFO, SPORTDiscus, Scopus, and key studies' reference lists.

Conclusion: Brief clinical tests (eg, gait, Timed Up and Go) can screen for neuropathy-related physical function deficits. Exercise and physical therapy may be promising treatments, but the efficacy and optimal dose of such treatments for chemotherapy-induced peripheral neuropathy are unclear.

Implications for nursing practice: Screening and assessment of neuropathy-associated physical function deficits should occur throughout neurotoxic chemotherapy treatment. If such deficits are identified, referral for rehabilitation (ie, physical or occupational therapy) and/or exercise interventions is warranted.

Keywords: Chemotherapy-induced peripheral Neuropathy; Exercise; Neuropathic pain; Physical therapy modalities; Rehabilitation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oncology Nursing / standards*
  • Peripheral Nervous System Diseases / chemically induced*
  • Peripheral Nervous System Diseases / physiopathology
  • Peripheral Nervous System Diseases / rehabilitation*
  • Physical Therapy Modalities / standards*
  • Practice Guidelines as Topic*
  • Rehabilitation Nursing / standards*