Nanoparticles guided drug delivery and imaging in gastric cancer

Semin Cancer Biol. 2021 Feb:69:69-76. doi: 10.1016/j.semcancer.2020.01.006. Epub 2020 Jan 16.

Abstract

Gastric cancer represents a deadly malignancy worldwide, yet current therapeutic regimens remain ineffective. Nanoparticle (NP) -based solutions could allow the design of novel therapeutic methods to eliminate this fatal disease. NPs typically carry out a significant role in multifunctional, multimodal imaging, and drug delivery carriers. In the recent decade, they have emerged as candidate approaches for the design of novel treatment strategies. Tumor nanotherapeutics characteristically possess various distinct advantages compared to conventional anti-cancer medications, which suffer from nonspecific bio-distribution, low solubility, and poor bioavailability. In this review, we will discuss the application of NPs in diagnosis and controlled drug delivery in gastric cancer (GC). We will focus on various NPs-based strategies employed against GC.

Keywords: Controlled drug delivery; Gastric cancer; Imaging; Nanoparticles; Nanotherapeutics.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Biological Availability
  • Drug Delivery Systems*
  • Humans
  • Multimodal Imaging / methods*
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Stomach Neoplasms / diagnostic imaging
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / pathology

Substances

  • Antineoplastic Agents