Taking the Brakes Off Targeted Protein Degradation

Zuzanna Kozicka; Georg Petzold; Nicolas H Thomä

doi:10.1016/j.chembiol.2019.12.010

Taking the Brakes Off Targeted Protein Degradation

Cell Chem Biol. 2020 Jan 16;27(1):16-18. doi: 10.1016/j.chembiol.2019.12.010.

Authors

Zuzanna Kozicka¹, Georg Petzold², Nicolas H Thomä³

Affiliations

¹ Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; University of Basel, Basel, Switzerland.
² Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
³ Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. Electronic address: nicolas.thoma@fmi.ch.

PMID: 31951816
DOI: 10.1016/j.chembiol.2019.12.010

Abstract

PCSK9 heightens LDL cholesterol levels by chaperoning the liver LDL receptor to lysosomes for degradation. In this issue of Cell Chemical Biology, Petrilli et al. (2020) identify novel PCSK9 ligands and convert them into a proof-of-concept degrader, offering a unique way to modulate this key protein-protein interaction.

Publication types

Comment

MeSH terms

Cholesterol, LDL
Ligands
Proprotein Convertase 9*
Proteolysis

Substances

Cholesterol, LDL
Ligands
PCSK9 protein, human
Proprotein Convertase 9