Current Nanoparticle Approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review

Mohammad A Ansari; Ill-Min Chung; Govindasamy Rajakumar; Mohammad A Alzohairy; Mohammad N Alomary; Muthu Thiruvengadam; Faheem H Pottoo; Niyaz Ahmad

doi:10.2174/1381612826666200116153912

Current Nanoparticle Approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review

Curr Pharm Des. 2020;26(11):1128-1137. doi: 10.2174/1381612826666200116153912.

Authors

Mohammad A Ansari¹, Ill-Min Chung², Govindasamy Rajakumar², Mohammad A Alzohairy³, Mohammad N Alomary⁴, Muthu Thiruvengadam², Faheem H Pottoo⁵, Niyaz Ahmad⁶

Affiliations

¹ Department of Epidemic Disease Research, Institutes for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia.
² Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, Korea.
³ Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Qassim 51431, Saudi Arabia.
⁴ National Center of Biotechnology, Life Science and Environmental Research Institute, King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabia.
⁵ Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam 31441, Saudi Arabia.
⁶ Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.

PMID: 31951165
DOI: 10.2174/1381612826666200116153912

Abstract

Nanoparticles (NPs) are unique may be organic or inorganic, play a vital role in the development of drug delivery targeting the central nervous system (CNS). Intranasal drug delivery has shown to be an efficient strategy with attractive application for drug delivery to the CNS related diseases, such as Parkinson's disease, Alzheimer 's disease and brain solid tumors. Blood brain barrier (BBB) and blood-cerebrospinal fluid barriers are natural protective hindrances for entry of drug molecules into the CNS. Nanoparticles exhibit excellent intruding capacity for therapeutic agents and overcome protective barriers. By using nanotechnology based NPs targeted, drug delivery can be improved across BBB with discharge drugs in a controlled manner. NPs confer safe from degradation phenomenon. Several kinds of NPs are used for nose to the brain (N2B) enroute, such as lipidemic nanoparticles, polymeric nanoparticles, inorganic NPs, solid lipid NPs, dendrimers. Among them, popular lipidemic and polymeric NPs are discussed, and their participation in anti-cancer activity has also been highlighted in this review.

Keywords: Nanoparticles; anticancer; intranasal drug delivery; nose to brain drug delivery; polymeric; therapeutic agents..

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Administration, Intranasal
Blood-Brain Barrier / physiology
Brain / physiology
Drug Delivery Systems*
Nanoparticles*