RETRACTED: Bone marrow mesenchymal stem cells-derived exosomal microRNA-185 represses ventricular remolding of mice with myocardial infarction by inhibiting SOCS2

Int Immunopharmacol. 2020 Mar:80:106156. doi: 10.1016/j.intimp.2019.106156. Epub 2020 Jan 13.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the integrity of the images in Figures 5B and 7C, which appear to contain suspected duplications, as detailed here: https://pubpeer.com/publications/C968FDCECE2069D7FF43B346B261ED and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. Numerous additional suspected image duplications were detected within Figures 5 and 6. Most of these image duplications involve either pasting portions of one image into another, or rotating/flipping the image. The journal requested the corresponding author comment on these concerns and provide the raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Mesenchymal stem cells-derived exosome; MicroRNA-185; Myocardial infarction; Suppressor of cytokine signaling 2; Ventricular remolding.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Apoptosis / immunology
  • Cell Line
  • Disease Models, Animal
  • Echocardiography
  • Exosomes / metabolism
  • Exosomes / transplantation
  • Heart Ventricles / cytology
  • Heart Ventricles / diagnostic imaging
  • Heart Ventricles / immunology
  • Heart Ventricles / pathology
  • Humans
  • Male
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / metabolism*
  • Mice
  • MicroRNAs / metabolism*
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / genetics*
  • Myocardial Infarction / immunology
  • Myocardial Infarction / therapy
  • Myocytes, Cardiac
  • Suppressor of Cytokine Signaling Proteins / genetics*
  • Ventricular Remodeling / genetics*
  • Ventricular Remodeling / immunology

Substances

  • MicroRNAs
  • Mirn185 microRNA, mouse
  • Socs2 protein, mouse
  • Suppressor of Cytokine Signaling Proteins