Discrimination of antibiotic-resistant Gram-negative bacteria with a novel 3D nano sensing array

Chem Commun (Camb). 2020 Feb 6;56(11):1717-1720. doi: 10.1039/c9cc09462h.

Abstract

A novel sensor array based on a (+)AuNP/AuNC nanocomposite was constructed for the selective discrimination of 10 types of Gram-negative bacteria (including 3 types of antibiotic-resistant strains) at a low concentration level of OD600 = 0.015. By recognizing the triple optical patterns of Gram-negative bacteria with the assistance of LDA, the sensor array is able to group the bacteria with respect to their species to each other.

MeSH terms

  • Bacterial Typing Techniques / methods*
  • Cluster Analysis
  • Discriminant Analysis
  • Gold / chemistry
  • Gram-Negative Bacteria / classification
  • Gram-Negative Bacteria / isolation & purification*
  • Gram-Positive Bacteria / classification
  • Gram-Positive Bacteria / isolation & purification
  • Humans
  • Metal Nanoparticles / chemistry*
  • Nanocomposites / chemistry
  • Scattering, Radiation
  • Spectrometry, Fluorescence
  • Urine / microbiology
  • Vancomycin / chemistry

Substances

  • Vancomycin
  • Gold