The role of fenhexamid on the proliferation of ovarian cancer BG-1 cells

Anxing Fei; Handong Fu; Hong Jiang; Liping Wei; Hongxia Zhang; Anqiong Fei; Yan Zhang; Tiantian Zou; Shuzhen Gao; Lin Li; Hong Jiang; Min Zhou; Hui Xing; Yanli Huang

The role of fenhexamid on the proliferation of ovarian cancer BG-1 cells

Int J Clin Exp Pathol. 2018 Apr 1;11(4):2025-2031. eCollection 2018.

Authors

Anxing Fei¹, Handong Fu², Hong Jiang¹, Liping Wei¹, Hongxia Zhang¹, Anqiong Fei³, Yan Zhang¹, Tiantian Zou¹, Shuzhen Gao¹, Lin Li⁴, Hong Jiang⁴, Min Zhou⁴, Hui Xing⁴, Yanli Huang⁴

Affiliations

¹ Laboratory Department (Clinical Laboratory) of Huangshi Maternal and Child Health Hospital Huangshi 435000, Hubei, P. R. China.
² Xiaogan Hospital Affiliated to Wuhan University of Science and Technology Xiaogan 432100, Hubei, P. R. China.
³ Daye General Hospital Huangshi 435100, Hubei, P. R. China.
⁴ Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Hubei University of Arts and Science Xiangyang 441021, Hubei, P. R. China.

PMID: 31938309
PMCID: PMC6958182

Abstract

To study the influence of fenhexamid in pesticide residue to the human ovarian cancer BG-1 cell proliferation. Detecting the effectiveness of 17β-estradiol, fenhexamid and Fulvestrant to BG-1 cell proliferation by MTT, and detecting the expression levels of cyclin D1 and cyclin E by Western blot. Fenhexamid can promote BG-1 cell proliferation for its estrogen-like effect. On the other hand, it can help to improve the expression levels of cyclin D1 and cyclin E in BG-1 cells which is regulated by ER-dependent pathway. And 17β-estradiol is also regulated by the same way. The existence of fenhexamid can promote ovarian cancer cell proliferation, so for patients with ovarian cancer, fenhexamid in pesticide residue may make medical conditions worse.

Keywords: Ovarian cancer; fenhexamid; pesticide residues.

Publication types

Retracted Publication