Schwarzinicines A-G, 1,4-Diarylbutanoid-Phenethylamine Conjugates from the Leaves of Ficus schwarzii

Premanand Krishnan; Fong-Kai Lee; Veronica Alicia Yap; Yun-Yee Low; Toh-Seok Kam; Kien-Thai Yong; Kang-Nee Ting; Kuan-Hon Lim

doi:10.1021/acs.jnatprod.9b01160

Schwarzinicines A-G, 1,4-Diarylbutanoid-Phenethylamine Conjugates from the Leaves of Ficus schwarzii

J Nat Prod. 2020 Jan 24;83(1):152-158. doi: 10.1021/acs.jnatprod.9b01160. Epub 2020 Jan 14.

Authors

Premanand Krishnan¹, Fong-Kai Lee¹, Veronica Alicia Yap¹, Yun-Yee Low², Toh-Seok Kam², Kien-Thai Yong³, Kang-Nee Ting¹, Kuan-Hon Lim¹

Affiliations

¹ School of Pharmacy , University of Nottingham Malaysia , Jalan Broga , 43500 Semenyih , Selangor , Malaysia.
² Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia.
³ Institute of Biological Sciences, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia.

PMID: 31935094
DOI: 10.1021/acs.jnatprod.9b01160

Abstract

Schwarzinicines A-G (1-7), representing the first examples of 1,4-diarylbutanoid-phenethylamine conjugates, were isolated from the leaves of Ficus schwarzii. The structures of these compounds were determined by detailed analysis of their MS, 1D and 2D NMR data. Compounds 1-4 exhibited pronounced vasorelaxant effects in the rat isolated aorta (E_max 106-120%; EC₅₀ 0.96-2.10 μM). However, compounds 1 and 2 showed no cytotoxic effects against A549, MCF-7, and HCT 116 human cancer cells (IC₅₀ > 10 μM).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line, Tumor
Ficus / chemistry*
HCT116 Cells
Humans
Molecular Structure
Phenethylamines / chemistry*
Phenethylamines / isolation & purification
Phenethylamines / pharmacology
Plant Leaves / chemistry*
Rats

Substances

Antineoplastic Agents, Phytogenic
Phenethylamines