Minocycline-EDTA-Ethanol Antimicrobial Catheter Lock Solution Is Highly Effective In Vitro for Eradication of Candida auris Biofilms

Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02146-19. doi: 10.1128/AAC.02146-19. Print 2020 Mar 24.

Abstract

Candida auris is an emerging pathogen that can cause virulent central-line-associated bloodstream infections. Catheter salvage through the eradication of biofilms is a desirable therapeutic option. We compared taurolidine and minocycline-EDTA-ethanol (MEE) catheter lock solutions in vitro for the eradication of biofilms of 10 C. auris strains. MEE fully eradicated all C. auris biofilms, while taurolidine lock partially eradicated all of the C. auris biofilms. The superiority was significant for all C. auris strains tested (P = 0.002).

Keywords: Candida auris; antimicrobial agents; biofilm; catheter lock solution; minocycline-EDTA-ethanol.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Biofilms / drug effects*
  • Biofilms / growth & development
  • Candida / drug effects*
  • Candida / growth & development
  • Candidiasis / drug therapy
  • Candidiasis / prevention & control
  • Catheter-Related Infections / drug therapy*
  • Catheter-Related Infections / prevention & control
  • Central Venous Catheters / adverse effects
  • Central Venous Catheters / microbiology
  • Edetic Acid / therapeutic use*
  • Ethanol / therapeutic use*
  • Humans
  • Minocycline / therapeutic use*
  • Taurine / analogs & derivatives
  • Taurine / therapeutic use
  • Thiadiazines / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Thiadiazines
  • Taurine
  • Ethanol
  • taurolidine
  • Edetic Acid
  • Minocycline