Severe nephritis as initial sign of Waldenström's macroglobulinemia

Thomas Knoop; Kristin Kampevold Larsen; Friedemann Leh; Anette Lodvir Hemsing; Ingrid Anna Teigen; Håkon Reikvam

doi:10.4081/cp.2019.1184

Severe nephritis as initial sign of Waldenström's macroglobulinemia

Clin Pract. 2019 Dec 19;9(4):1184. doi: 10.4081/cp.2019.1184. eCollection 2019 Nov 5.

Authors

Thomas Knoop^{1

2}, Kristin Kampevold Larsen³, Friedemann Leh³, Anette Lodvir Hemsing¹, Ingrid Anna Teigen⁴, Håkon Reikvam^{1

5}

Affiliations

¹ Department of Medicine, Haukeland University Hospital.
² Institute of Medical Science, University of Bergen.
³ Department of Pathology, Haukeland University Hospital.
⁴ Department of Pharmacology, Haukeland University Hospital.
⁵ Institute of Clinical Science, University of Bergen, Bergen, Norway.

Abstract

Waldenström's macroglobulinemia (WM), characterized with monoclonal immunoglobulins of type M and lymphoplasmacytic lymphoma, is a rare clonal Bcell disorder. WM usually present as an indolent lymphoma, and renal involvement is, in contrast to multiple myeloma, very rarely seen. We present a patient presenting with severe nephritis and nephrotic range proteinuria of more than 9 g/day as initial manifestations of WM. Furthermore, we discuss diagnostic and therapeutic approaches for this rare manifestation of the disease, in the light of recent research and treatment recommendations.

Keywords: Nephrite; Waldenström’s macroglobulinemia; hypertension; proteinuria.

Grants and funding

Funding: the study was supported by Helse Vest and the Norwegian Cancer Society.