Prolonged plasma glucose elevation on oral glucose tolerance test in young healthy Japanese individuals

Hirotaka Ishigaki; Akihiro Yoshida; Osamu Araki; Takao Kimura; Katsuhiko Tsunekawa; Yoshifumi Shoho; Makoto Nara; Tomoyuki Aoki; Takayuki Ogiwara; Masami Murakami

doi:10.1002/edm2.98

Prolonged plasma glucose elevation on oral glucose tolerance test in young healthy Japanese individuals

Endocrinol Diabetes Metab. 2019 Oct 28;3(1):e00098. doi: 10.1002/edm2.98. eCollection 2020 Jan.

Affiliations

¹ Department of Clinical Laboratory Medicine Gunma University Graduate School of Medicine Maebashi Japan.
² Infection Control and Prevention Center Gunma University Hospital Maebashi Japan.
³ Internal Medicine Division of Endocrinology and Diabetes Saiseikai Maebashi Hospital Maebashi Japan.

PMID: 31922025
PMCID: PMC6947704
DOI: 10.1002/edm2.98

Abstract

Aims: This study aims to assess insulin secretion and resistance through oral glucose tolerance test (OGTT) among young Japanese individuals.

Subjects and methods: We enrolled 595 young healthy Japanese individuals aged 22-29 years. They underwent an OGTT, and their results were divided into 4 groups (I-IV), according to the time at which their plasma glucose concentration declined below the fasting glucose concentration (30, 60 or 120 minutes or never as groups I, II, III and IV, respectively).

Results: We classified 575 normal glucose-tolerant subjects into 4 groups (I-IV) with I: 28 (4.9%), II: 120 (20.9%), III: 143 (24.9%) and IV: 284 (49.4%) individuals. The Matsuda, insulinogenic and disposition indices were decreased from groups I to IV. ROC curves of disposition index reflecting the composition of insulin secretion and sensitivity classified the prolonged glucose elevation group (group III + IV) from the rapid glucose lowering group (group II; AUC = 0.847).

Conclusions: Even in a young and healthy Japanese individual within the physiological range of glycaemic control, there is a sequential decrease in insulin sensitivity and secretion.

Keywords: disposition index; high‐density lipoprotein cholesterol; insulin secretion; oral glucose tolerance test; young Japanese.