Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections

Yu-Xuan Ma; Chen-Yu Wang; Yuan-Yuan Li; Jing Li; Qian-Qian Wan; Ji-Hua Chen; Franklin R Tay; Li-Na Niu

doi:10.1002/advs.201901872

Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections

Adv Sci (Weinh). 2019 Dec 5;7(1):1901872. doi: 10.1002/advs.201901872. eCollection 2020 Jan.

Authors

Yu-Xuan Ma¹, Chen-Yu Wang¹, Yuan-Yuan Li¹, Jing Li¹, Qian-Qian Wan¹, Ji-Hua Chen¹, Franklin R Tay^{1

2}, Li-Na Niu^{1

2}

Affiliations

¹ State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University 145 Changle West Road Xi'an Shaanxi 710032 P. R. China.
² The Graduate School Augusta University 1430, John Wesley Gilbert Drive Augusta GA 30912-1129 USA.

Abstract

ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are among the most common opportunistic pathogens in nosocomial infections. ESKAPE pathogens distinguish themselves from normal ones by developing a high level of antibiotic resistance that involves multiple mechanisms. Contemporary therapeutic strategies which are potential options in combating ESKAPE bacteria need further investigation. Herein, a broad overview of the antimicrobial research on ESKAPE pathogens over the past five years is provided with prospective clinical applications.

Keywords: antimicrobial peptides; antiresistance; antivirulence; bacteriophages; nanodelivery strategies.

Publication types

Review