Molecular biology of oral cavity squamous cell carcinoma

Abstract

Oral cavity squamous cell carcinoma (OCSCC) is a heterogeneous and complex disease that arises due to dysfunction of multiple molecular signaling pathways. Recent advances in high-throughput genetic sequencing technologies coupled with innovative analytical techniques have begun to characterize the molecular determinants driving OCSCC. An understanding of the key molecular signaling networks underlying the initiation and progression of is essential for informing treatment of the disease. In this chapter, we discuss recent findings of key genes altered in OCSCC and potential treatments targeting these genes.

Keywords: Cancer genetics; Epigenetics; HNSCC; Head and neck cancer; Head and neck squamous cell carcinoma; Immunotherapy; Molecular biology of oral cavity squamous cell carcinoma; Oral cancer; Oral cavity cancer; Squamous cell carcinoma.