Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections

Clin Infect Dis. 2020 Oct 23;71(7):1772-1775. doi: 10.1093/cid/ciaa022.

Abstract

Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT01790698 and NCT02111161.

Keywords: Streptococcus pyogenes; intravenous immunoglobulin G; necrotizing fasciitis; necrotizing soft tissue infections; superantigens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fasciitis, Necrotizing* / drug therapy
  • Humans
  • Immunoglobulins, Intravenous
  • Plasma
  • Soft Tissue Infections* / drug therapy
  • Streptococcal Infections* / drug therapy
  • Streptococcus pyogenes
  • Superantigens

Substances

  • Immunoglobulins, Intravenous
  • Superantigens

Associated data

  • ClinicalTrials.gov/NCT02111161
  • ClinicalTrials.gov/NCT01790698